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Longitudinal plasma metabolomics of aging and sex

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“NNMT plays a key role in metabolic dysfunction, and its inhibition has been shown to reverse obesity-related changes in adipose tissue.” — Kraus et al., Cell Metabolism How 5-Amino-1MQ Works The primary mechanism behind 5-Amino-1MQ lies in its ability to inhibit nicotinamide N-methyltransferase (NNMT) — an enzyme that is often overexpressed in fat cells, cancer cells, and aging tissues