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To determine whether the internal Mg 2+ concentration was the same as that in bulk solution, we measured the Mg 2+ activity inside vesicles by encapsulating the Mg 2+ -sensitive dye mag-fura-2 (Supplementary Fig

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The copper component of the peptide serves as an essential cofactor for lysyl oxidase and lysyl hydroxylase , enzymes critical for proper collagen cross-linking and stability