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Consequently, disruptions in GSH biosynthesis, utilization, or recycling are hallmarks of oxidative stress and have been implicated in the pathogenesis of aging, neurodegenerative diseases like Parkinson’s and Alzheimer’s, cancer, and various metabolic disorders [37]

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Keywords: SIRT1, aging, cellular senescence, liver diseases, therapeutic approaches Graphical Abstract 1 Introduction Aging is a fundamental biological process that affects the functionality of various organs (Li et al., 2024), including the liver, which is critical for metabolic homeostasis, detoxification, and energy regulation (Liangyou, 2014