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Abbreviations PDB Protein Data Bank Rms root-mean-square TRP1 tyrosinase-related protein 1 UV-vis ultraviolet-visible Data Availability Coordinates and structure factors of tyrosinase complexed with the caddie protein have been deposited in the RCSB Protein Data Bank under accession code 5Z0D for ST1, 5Z0E for ST2, 5Z0F for ST3, 5Z0G for ST4, 5Z0H for ST5, 5Z0I for ST7, 5Z0J for ST8, 5Z0K for ST9, 5Z0L for ST10, and 5Z0M for ST6
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Concerning activating Met kinase domain mutations, Park and Di Renzo and Lee and Aebersold (Park et al., 1999