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In the cell culture experiments, the researchers treated epithelial cells sourced from the African Green Monkey Kidney (VeroE6), human bronchial epithelial cell lines (Beas 2 B) and human non-small cell lung cancer cell lines (H46) to explore the impact of hesperidin on viral infection, particularly its efficacy in hindering the entry of SARS-CoV-2 pseudoparticles containing both wild-type and variant spike proteins