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In turn, GSSG is reduced by glutathione reductase in the presence of nicotinamide adenine dinucleotide phosphate [NAD(P)H], which is generated mainly in the pentose phosphate pathway, as shown in the following equations: 2GSH+?2?2→GSSG+2?2?GSSG+NADPH+?+→2GSH+NADP+ Glutathione is a widely distributed thiol in animal organisms, not only in somatic cells but also in the gametes