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In T cell activation, glutamine deprivation has been shown to alter the activation of naive CD4 + T cells and result in their differentiation into forkhead box P3-positive (Foxp3 + ) regulatory T (T reg ) cells, which have suppressor functions 109

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Severe diarrhea (more than 6 episodes daily, blood in stool, inability to stay hydrated) warrants medical evaluation, but the solution may be a dose reduction or extended hold at the current dose rather than complete discontinuation