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The availability of chemical libraries and high-throughput phenotypic screening platforms enabled the discovery of a series of small molecules that triggered an iron-dependent, oxidative, non-apoptotic form of cell death by preventing the uptake of cystine by the system xCT cystine/glutamate antiporter (i.e., erastin) or by covalently inhibiting GPX4 (i.e., rat sarcome (RAS) selective lethal 3 (RSL3)) [[25], [26], [27], [28], [29]]