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Unlike ulcerative colitis, which is limited to the colonic mucosa, Crohn’s disease features skip lesions — areas of diseased bowel separated by segments of normal-appearing tissue — and may involve multiple layers of the intestinal wall, leading to fibrosis, stricture formation, and fistulization, as described by the Crohn’s & Colitis Foundation
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Cycle lengths of 4 to 8 weeks are most common for acute injuries
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