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Thus, BPC 157 therapy can interfere in a controlling particular way with diazepam tolerance as a mechanism operative in neuronal circuit adaptation to the extreme amplification of GABA-gated Cl − current intensities [219]

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A peptide such as KPV (lysine-proline-valine, a C-terminal fragment of α-MSH) has been studied for anti-inflammatory effects on the intestinal epithelium, and it is taken up locally by the intestinal transporter PepT1