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Previously, it was suggested that chronic inflammation in DES is associated with an imbalance between omega-3 (docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA)) and omega-6 (arachidonic acid (AA)) PUFAs, which lead to the hyperproduction of proinflammatory lipid mediators (omega-6 derivative oxylipins, such as prostaglandins) and underproduction of proresolving (omega-3 derivative oxylipis) molecules [21]
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