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Introduction Iron is an essential mineral nutrient involved in numerous biologic processes, namely, heme synthesis, iron-dependent catalytic reaction, DNA synthesis, and mitochondrial respiration ( via the Haber–Weiss–Fenton reactions, causing oxidative damage to cellular components like lipids, proteins, and DNA ( In 1981, Jerome Sullivan proposed the iron hypothesis to explain the sex differences in the risk of heart disease and the lower incidence of CVD in premenopausal women ( The precise mechanisms of iron homeostasis in the cardiovascular system are distinct and complicated

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In addition, the increase in hydrogen peroxide production due to the suppression of GPx1 resulted in a proinflammatory activation of human endothelial cells, as characterized by the upregulation of the adhesion molecules ICAM1 and VCAM1

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