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In healthy aging, attenuated circadian amplitude and phase shifts may represent adaptive recalibration of the circadian system, optimizing energy expenditure, sleep–wake timing, and metabolic processes under age-related physiological constraints

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Programmed cell death (PCD), including apoptosis, necroptosis, pyroptosis, autophagy and ferroptosis, is a genetically regulated process essential for tissue homeostasis and pathogen defense (29)