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In contrast, IRP2 knockdown or treatment with the ferroptosis inhibitor Fer-1 alleviates PC-12 cell damage by downregulating p53 levels and activating the SLC7A11-ALOX12 signaling pathway (Yao et al., 2024)
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This is particularly crucial in highly secretory cells such as pancreatic β-cells, where efficient insulin production depends on intact Golgi dynamics
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